3)Immune Responses with Aging

Self-compassionate responses to aging.

PURPOSE Evidence suggests that self-compassion may be beneficial to older adults who are struggling to cope with the aging process. The purpose of this study was to assess the thoughts of self-compassionate older adults and to determine whether self-compassionate thoughts relate to positive responses to aging. DESIGN AND METHODS Participants (n = 121, M = 76.2 years, approximately 65% female)...

Dopaminergic responses in the Fischer 344 rat heart: preserved chronotropic and dromotropic responses with aging.

BACKGROUND Marked decreases in cardiac responses to beta-adrenergic stimuli have been found in cellular, animal, and human models of physiologic aging. As another probe of receptor-regulated cardiovascular changes with aging, responses to dopamine were studied. Responses were studied with and without depletion of myocardial catecholamines to eliminate effects secondary to myocardial catecholami...

Aging impairs vasodilatory responses in rats

BACKGROUND Aging causes profound changes of stiffness and compliance in the cardiovascular system, which contributes to decreased cardiovascular reserve. Mechanisms of the underlying endothelial vasodilator dysfunction in vasodilator signaling pathways may occur at multiple sites within any of these pathways. METHODS Age-related changes in the vasculature were investigated in adult young (3-6...

Aging Ergonomics: A Field with Inadequate Notice

Hypoxic and hypercapnic ventilatory responses in aging male vs. aging female rats.

It is clear that sex hormones impact ventilation. While the effects of the menstrual cycle, pregnancy, testosterone, and progesterone on resting ventilation have been well documented, effects of sex hormones on the hypoxic (HVR) and hypercapnic ventilatory responses (HCVR) are inconclusive. In addition, in no study have systemic sex steroid hormone levels been measured. Age and sex differences ...